About

Our Story

Understanding how and why some people’s lungs are unable to defend themselves against infection has been at the heart of the Synairgen story.

Who are Synairgen?

In the 1970s, British immunophysician Professor Sir Stephen Holgate, began investigating how respiratory viruses can cause serious illness, with the aim of translating these insights into effective clinical treatments. Joined by fellow University of Southampton professors Donna Davies and Ratko Djukanovic, the three formed Synairgen in 2003 with the sole aim of bringing these advances to patients.

Pioneers of using ex vivo models, which use cells collected from patients with respiratory disease, Synairgen was able to make major advances in the understanding of the defence mechanisms of the human lung. This ground-breaking research showed that interferon beta (IFN-β) was an essential component in an effectively functioning respiratory defence system, and any deficiencies in this naturally occurring protein were likely to lead to serious illness and even death.

Synairgen has developed SNG001, an inhaled formulation of IFN-β designed to directly target the lungs, the primary site of many viral lung infections.

SNG001 has been tested in several clinical studies in both out-patient and hospital settings and was found to boost lung antiviral responses, accelerate viral clearance from the lungs, be well tolerated and show potential for clinical benefit in patients with various respiratory infections.

Our Founders

Professor Sir Stephen Holgate is a co-founder of Synairgen and was appointed a non-executive director in June 2003. He is the Medical Research Council Clinical Professor of Immunopharmacology at the University of Southampton.

Professor Sir Stephen Holgate is a co-founder of Synairgen and was appointed a non-executive director in June 2003. He is the Medical Research Council Clinical Professor of Immunopharmacology at the University of Southampton.

Professor Ratko Djukanovic is a co-founder of Synairgen and Professor of Medicine at University of Southampton.

Professor Ratko Djukanovic is a co-founder of Synairgen and Professor of Medicine at University of Southampton.

A co-founder of Synairgen, Professor Donna Davies is Professor of Respiratory Cell and Molecular Biology, within Medicine at the University of Southampton.

A co-founder of Synairgen, Professor Donna Davies is Professor of Respiratory Cell and Molecular Biology, within Medicine at the University of Southampton.

Interferon Beta

Discover how IFN-β has been shown in the laboratory to protect cells from infection from a wide variety of seasonal respiratory and pandemic viruses including RSV, rhinovirus, various influenza strains including H5N1, and MERS-CoV.