Shareholders with interests of over 3% (Significant Shareholders), as advised to the Company, are listed to the right.

In so far as the Company is aware, the percentage of the Company's issued share capital that is not in public hands is 56.6%. This percentage comprises the holdings of Woodford Investment Management, Lansdowne Partners, Richard Griffiths and the directors' beneficial holdings of 3.9%.

Name of shareholderNumber of ordinary shares% of share capital
Woodford Investment Management 21,091,651 23.1%
Lansdowne Partners 16,923,111 18.5%
Richard Griffiths 10,136,512 11.1%
Southampton Asset Management Limited 3,600,000 3.9%
Leonard Licht 3,700,000 4.1%